Another good day for Big Mushroom. Researchers dosed aged mice with psilocybin and not only did they live longer, but they likely had a lot of fun doing so. In cell studies, psilocybin extended cellular lifespan by up to 57%. Amongst “other” effects, the compound preserved telomere length which is the bit of chromosomes that tends to fray as you age.

When 19-month-old mice (roughly equivalent to retirement-age humans) received monthly psilocybin doses, 80% were still kicking compared to just 50% of their sober counterparts. The treated mice even showed better fur quality and less greying, all meaning it may soon get significantly harder to keep classifying this as a purely recreational drug. 

🧐 What's in it for me? Human trials are still years away, but the FDA has already blessed psilocybin as a "breakthrough therapy" for depression, so at least we know it won't kill you, which, ironically, is more than can be said for many other anti-ageing fads.

💵 Out of the Lab: As wealth continues to concentrate, and the hands into which its concentrated continue to age, this is the kind of research that is likely to attract a number of benefactors. 

  • One of the researchers, Kosuke Kato has already launched PsiloHeal LLC, possibly to commercialise these findings.

  • Compass Pathways (NASDAQ: CMPS) has spent years navigating regulators, for better and worse, and has earned their position in the market.

  • Cybin and ATAI Life Sciences have also planted flags in psychedelic medicine, though they've focused more on neurology.

Until next time, stay curious.

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